Wednesday, October 7, 2009

Mesothelioma Clinical Trials - A Good Option?

Mesothelioma Clinical Trials - A Good Option?

Mesothelioma is an insidious form of cancer because of the fact it is often discovered so late that treatment options are simply non-existent. For many people, the only option is to consider clinical trials. The question is whether this is a good option.
What are clinical trials? They are testing periods for new drugs or procedures that may eventually prove effective and be approved by the FDA as a treatment for something. Put another way, they are the process of testing whether a drug or procedure does what it is intended to do. Sometimes they do. Sometimes they don't.

Mesothelioma is a brutally difficult cancer to deal with for a unique reason. The problematic characteristic is it is very hard to find until it is too late for the patient. A person can have the cancer for 10, 20 or 30 years during which it can be treated, but still die of it because it went undetected. Given this problem, there are many different clinical trials going on all the time devoted to Mesothelioma treatments. For example, one related to the Mesomark, which is a promising new blood test that can lead to early detection.

Is it safe to take part in clinical trials? Generally, the answer is that it is safe to do so. A drug company does not just produce a drug and then start testing it on people. It must undergo testing and vetting processes before that happens. Still, clinical trials are undisputedly a form of experiment. The researchers think the drug or procedure being tested will work, but aren't sure. This is, after all, why they have not been approved as of yet. The downside is usually just ineffectiveness, but side effects and rarely even death can occur.

Should you submit to clinical trials if you have Mesothelioma? The decision is entirely up to you. A late stage diagnosis of Mesothelioma is very often fatal, so there may be little choice.

Friday, September 25, 2009

What are symptoms of Mesothelioma

What are symptoms of Mesothelioma

The term "Mesothelioma" in medical terms is defined as form of cancer that proliferates at a very fast rate after it has been diagnosed, which affects the mesothelial cells in the body. After detailed study of this disease by several scientists all over the world, it has been concluded that in most of the cases the reason is the direct contact with loose asbestos particles. This disease is generally known to be derived from an abnormality that arises from inhaling the loose asbestos particles suspended in the air for a very long time. The chances of the patients, diagnosed of mesothelioma, have very bleak chances of survival which is not more than one or two years and if it has been detected long back and rigorous medication has been started on the patient then the patient is likely to live for about five years.

There are three types of mesothelioma but the symptoms of the diseases depend on their kinds. The symptoms vary from one-another but the general symptoms that are found in patients suffering from different types of mesothelioma are weight loss, chest pain, loss of appetite, short breath , plain cough and cough with blood. Diagnosing mesothelioma in its initial stages is not possible because symptoms surface very late and that, these symptoms are no special signs indicating the particular disease but are common for other diseases too.

Generally the symptoms of mesothelioma resemble to that to any other normal lung diseases. Most of the symptoms arise in the lungs, where the mesothelial cells covering the lungs and the cavity between them are affected due to prolonged inhalation of asbestos fibers. Consulting with the physician is very necessary from time to time and necessary test must be conducted to detect the disease.

The main symptom of mesothelioma is a constant pain in the chest which is followed by short breaths and difficult breathing because of accumulation of fluid in the chest, which makes breathing all the more difficult. Some of the other symptoms of the disease include abnormalities in the lungs, which can be diagnosed under proper supervision of the doctor with a chest CT-scan.

Basically, the disease of mesothelioma advances in four stages. In the first stage, begins the formation of the tumor in the area of lining of the lung and doesn't exceed from one side of the lung. And then in the second stage the tumor extends to other organs in the chest cavity, such as heart. Then in the third stage its extents to the other abdominal organs affecting all the other organs too. Finally in the fourth and the last stage the tumor extends to all parts of the body and affects all the parts adversely. These are some of the symptoms of the disease of mesothelioma, by which the disease can be tracked in the initial stages of its occurrence.

Mesothelioma Surgery India - Mesothelioma Surgery Why Come To India

Mesothelioma Surgery India - Mesothelioma Surgery Why Come To India

Mesothelioma Cancer

Malignant mesothelioma is a rare cancer that occurs in the thin layer of tissue that covers the majority of your internal organs (mesothelium).

Doctors divide mesothelioma into different types based on what part of the mesothelium is affected, including : -



Malignant mesothelioma, which affects the tissue that surrounds the lungs and is the most common form of mesothelioma.



Peritoneal mesothelioma, which occurs in the tissue in your abdomen.



Pericardial mesothelioma, which affects the tissue surrounding the heart.



Mesothelioma of the tunica vaginalis, which occurs in the lining around the testicles.



Symptoms of Mesothelioma

Signs and symptoms of mesothelioma vary depending on where the cancer occurs.



Pleural mesothelioma signs and symptoms may include : -

Shortness of breath
Painful breathing (pleurisy)
Painful coughing
Chest pain under the rib cage
Unusual lumps of tissue under the skin on your chest
Unexplained weight loss
Dry (nonproductive) cough


Other forms of mesothelioma

Signs and symptoms of pericardial mesothelioma and mesothelioma of the tunica vaginalis are unclear. These forms are so rare that not much information is available. Pericardial mesothelioma signs and symptoms may include difficulty breathing or chest pains. Mesothelioma of the tunica vaginalis may be first detected as a mass on a testicle.



When to see a doctor

See your doctor if you have signs and symptoms that may indicate mesothelioma. Signs and symptoms of mesothelioma aren't specific to this disease and, due to the rarity of mesothelioma, are more likely to be related to other conditions. If any persistent signs and symptoms seem unusual or bothersome to you, ask your doctor to evaluate them.



Causes of Mesothelioma

In general, cancer begins when a series of genetic mutations occur within a cell, causing the cell to grow and multiply out of control, when healthy cells would normally die. The accumulating abnormal cells form a mass (tumor). Cancer cells invade nearby tissues and can break off from an initial tumor to spread elsewhere in the body (metastasize)...



Tests and diagnosis of Mesothelioma

If you have signs and symptoms that might indicate mesothelioma, your doctor will conduct a physical exam to check for any lumps or other unusual signs. Your doctor may order imaging scans, such as a chest X-ray or a computerized tomography (CT) scan of your chest or abdomen, to look for abnormalities.

It's not uncommon for mesothelioma to be misdiagnosed initially because mesothelioma is rare, and its signs and symptoms aren't specific. Your doctor will likely rule out other more common conditions before considering mesothelioma...



Treatments of Mesothelioma

What treatment you undergo for mesothelioma depends on your health and certain aspects of your cancer, such as its stage and location. Unfortunately, mesothelioma often is an aggressive disease and for most people a cure isn't possible. Mesothelioma is usually diagnosed at an advanced stage - when it isn't possible to remove the cancer through an operation. Instead, your doctor may work to control your cancer to make you more comfortable.

Discuss treatment goals with your doctor. Some people want to do everything they can to treat their cancer, even if that means enduring side effects for a small chance of an improvement. Others prefer treatments that make them comfortable so that they can live their remaining months as symptom-free as possible.



Surgery

Surgeons work to remove mesothelioma in instances where it is diagnosed at an early stage. Sometimes it isn't possible to remove all of the cancer. In those cases, surgery may help to reduce the signs and symptoms caused by mesothelioma spreading in your body...



Chemotherapy

Chemotherapy uses chemicals to kill cancer cells. Systemic chemotherapy travels throughout the body and may shrink or slow the growth of a pleural mesothelioma that can't be removed using surgery. Chemotherapy may also be used before surgery (neoadjuvant chemotherapy) to make an operation easier or after surgery (adjuvant chemotherapy) to reduce the chance that cancer will return...



Radiation therapy

Radiation therapy focuses high-energy beams to a specific spot or spots on your body. Radiation may reduce signs and symptoms in people with pleural mesothelioma. Doctors aim radiation at the entire chest to obtain the best result. However, many sensitive organs are in the chest, such as the heart, lungs, esophagus and spinal cord, so doctors must use low doses of radiation to spare these organs...



Combination therapy

Surgery, chemotherapy and radiation therapy may be combined. This aggressive therapy can be grueling and may not be appropriate for everyone. Younger, healthier people and those with earlier stage mesothelioma may be more able to endure this treatment. Combination therapy has shown the most promise in treating mesothelioma. However, most people will eventually experience a recurrence of this cancer despite aggressive treatment.



Treatment for other types of mesothelioma

Pericardial mesothelioma and mesothelioma of the tunica vaginalis are very rare and can be very aggressive. Early-stage cancer may be removed through surgery. Doctors have yet to determine the best way to treat later stage cancers, though. Your doctor may recommend other treatments to improve your quality of life.



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Important Tips on How You Can Participate in a Mesothelioma Clinical Trial

Important Tips on How You Can Participate in a Mesothelioma Clinical Trial

A clinical trial is a process that all new treatment options and medications go through before they are accepted and registered for general usage. These trials often offer a last hope for cure for many terminal and difficult diseases. Most drugs that have become standard therapies for many illnesses today have all undergone an extensive period of testing with clinical trials.
There are three stages of clinical trials. Phase I trials enroll a limited number of people. They normally center on the correct dosage and relative safety of a particular drug. Phase II trials enroll more people and are used to determine if the new drug actually works against a particular illness. Phase III trials are the final phase before a drug is approved for treating a disease. During Phase III, the new drug is compared against the existing treatment. The goal during Phase III is to prove the new drug is a more effective treatment.

To find about clinical trials you can participate in you can check on the internet for resources that list ongoing clinical trials for mesothelioma, which include the qualifications for each.

You can also consult your mesothelioma doctor for information on available clinical trials. Doctors have access to all upcoming and current clinical trials, and can also help determine if a patient qualifies for a particular trial.

You can also contact the large regional cancer centers in their area, which will have access to information on clinical trials being coordinated from their hospitals

You have to consider a lot of factors if you want to take part in a clinical trial. Clinical trials typically occur in large metropolitan hospitals and it is important to know how often participants will need to see the physicians coordinating the trials and how long each visit will take, these visits will translate into a lot of hotel and travel expenses.

Not everyone qualifies for a clinical trial, different trials use different criteria for selecting eligible participants. Some clinical trials want participants that that have undergone an unsuccessful traditional treatment, while other clinical trials want patients who have not been treated at all.

Mesothelioma is an aggressive form of asbestos cancer with an extremely low survival rate and clinical trials are one of the best ways to find a cure. The patients currently involved in mesothelioma clinical trials will hopefully pave the way for a more effective treatment. You must consult with your doctor about the various available clinical trials once you are diagnosed with mesothelioma.

Tuesday, September 22, 2009

Life Expectancy of Mesothelioma Patients

Life Expectancy of Mesothelioma Patients

In evaluating the life expectancy of mesothelioma patient, you need to take into consideration number of factors as every patient has a completely different case. Because scientists are working overtime to come up with a new treatment routine, there is no surprise that life expectancy of mesothelioma patients are increasing. For mesothelioma patients, the average life expectancy is in the range of five to eighteen months.
Factors you need to take into Consideration

* Disease stage * The diagnosis point * Kind of mesothelioma you are suffering from. It includes localized mesothelioma and advanced mesothelioma. * Your age * Your overall health * Kinds of treatment feasible for you

Stage of Mesothelioma Cancer

The mesothelioma cancer stage can give you a clear sign of how long you are going to live. As the mesothelioma symptoms in an initial stage are quite identical to other common ailments, there is always a possibility of mesothelioma patients not getting proper diagnosis. By the time disease is discovered, it has already entered the advanced stage which is not easy to treat and therefore much less life expectancy.

At this moment of time, there is no real cure available for mesothelioma cancer but with the help of various mesothelioma treatment routines, mesothelioma patients can increase their life expectancy especially if diagnosed early on in the piece. Contact mesothelioma centers immediately if you think that you have been exposed to asbestos. In these centers, you will get all the necessary details regarding testing for initial mesothelioma stages. Early Detection and Aggressive Treatment

Recent study has come to the conclusion that two of the most important factors in increasing the life expectancy of mesothelioma patient are early detection and aggressive treatment. With aggressive treatment, life expectancy of mesothelioma patients can be increased by more than two years. For early detection of mesothelioma, it is quite important that you do not wait for symptoms to start making its presence felt. Latency period and Mesothelioma

Unlike other forms of cancers in which symptoms surface quickly, mesothelioma symptoms can lay dormant in the body for more than thirty years. This long latency period quite a number of times result in a delayed diagnosis. In lots of cases, the diagnosis is made when the disease has reached advanced stage. This makes the whole mesothelioma treatment exercise ineffective. Patients diagnosed in advanced stages are going to get palliative treatments which are much more comfortable in nature but are not that effective in curing the disease. Smoking

According to latest research, smoking can reduce the life expectancy rate of people diagnosed with mesothelioma. Therefore, it is quite important that you get rid of your smoking habits once you are diagnosed with mesothelioma. Treatment options for Mesothelioma Patients

With regard to treatment options, you can go for radiation, chemotherapy and surgery. Before taking any decision, it is always better that you interact with your health care provider first.

Mesothelioma and Asbestos-A Deadly Alliance

Mesothelioma and Asbestos-A Deadly Alliance

Mesothelioma is a type of cancer that affects the thin membrane (called the mesothelium) lining the chest, lungs, abdomen and sometimes the heart. Mesothelioma is a relatively rare cancer with more than two hundred people affected in the US annually. The majority of mesothelioma cases are directly linked to asbestos exposure.
The disease has a very long latency period so most victims are of an average age of 50-70 years. Mesothelioma most often affects men, most of them were exposed to asbestos at their place of industrial typed jobs. Mesothelioma symptoms include respiratory problems, shortness of breath, continual cough and pneumonia. Other mesothelioma symptoms include weight loss, abdominal problems and swelling. In some mesothelioma patients, the mesothelioma symptoms are not very specific, making diagnosis very difficult.

Mesothelioma doctors specialize in the study, research, and treatments of Mesothelioma cancers. Mesothelioma (or the cancer of the mesothelium) is a disease in which cells become abnormal and replicate without control, these abnormal cells spread and invade other normal organs and tissues in the body. Mesothelioma cancer cells can spread throughout the body ultimately leading to death.

Mesothelioma treatments and Mesothelioma clinical trials and tests There are many mesothelioma treatment options available. The conventional treatments include surgery, radiation therapy and chemotherapy and the mesothelioma treatment depends on the patient's age, general health and stage of the cancer. There has however been much mesothelioma research conducted throughout the recent years to find new treatment methods. Through mesothelioma research, The National Cancer Institute has sponsored mesothelioma tests and clinical trials that are designed to find new treatment methods.

Because of the increase in number of mesothelioma cases in the United States, both governments have increased funding for mesothelioma research. Mesothelioma research and clinical trials have been successful in developing new techniques to fight this cancer and the outlook for more advanced mesothelioma treatments is promising.

Surgery is the most common treatment method for malignant mesothelioma. Tissues and linings affected by mesothelioma are removed by the doctor and may include the lung or even diaphragm.

A second mesothelioma treatment method is radiation therapy through the use of high energy x-rays that kill the cancer cells. Radiation therapy can be outside or inside the body.

A third mesothelioma treatment method is chemotherapy. Through pills or drugs through needles, chemotherapy drugs are used to kill cancer cells.

A new mesothelioma treatment method is called intraoperative photodynamic therapy. In this treatment, light and drugs are used to kill cancer cells during surgery for early stages of mesothelioma in the chest.

Although there are numerous treatments and drugs for mesothelioma, doctors are loosing the battle against this deadly disease. Most mesothelioma treatments involve old techniques combined with different drug cocktails. However, in most cases, these mesothelioma treatments have many side effects including organ damage, nausea, increase in heart failure etc. Research to find a more effective mesothelioma treatment or even cure is ongoing at numerous clinical labs across the nation. Let's hope that the mesothelioma research will one day lead to the discovery of an effective treatment to cure mesothelioma cancer and asbestosis.

Patients stricken by Mesothelioma and their families require support and current information. Mesothelioma Online Resources hopes to educate and give hope to survivors and victims. Such information can be obtained from http://www.mesotheliomacorner.blogspot.com

Mesothelioma is such a terrible disease. Not only does it take years for symptoms to appear, but there are limited treatments and drugs that only most of the time just prolong the lifespan of most patients by a few months to years. In many cases, the death rate of mesothelioma is unfortunately very high.

However, with increased funding in mesothelioma research through the government and private grants, the outlook for a mesothelioma cure is quite possible. In the meantime, mesothelioma support groups and local discussions provide the ongoing support for mesothelioma patients.

How Can Mesothelioma Pain Be Treated With the Use of Medication?

How Can Mesothelioma Pain Be Treated With the Use of Medication?

One of the main ways by which mesothelioma pain can be treated is with the use of proper medication.
However,the type of medicine and the way the medicine is given depend on the type and cause of pain. For example, chronic pain is best relieved by methods that deliver a steady dose of pain medicine over a long period of time, such as a patch that releases medicine through the skin or slow-release oral tablets. On the other hand, breakthrough pain {Breakthrough pain is flare of pain that happens even though you are taking pain medicine regularly for persistent pain. It's called breakthrough pain because it "breaks through" the pain relief you get from the regular pain medicine schedule}is best treated with medicines that work fast (quick release), but stay in the system only for a short time.

Below is an overview of the types of medicines used to relieve pain.

For mild to moderate pain

Non-opioids: Acetaminophen (Tylenol®) and non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen are often used.

You can buy many of these over the counter (without a prescription). For others, you need a prescription. Check with your doctor before using these medicines. NSAIDs can slow blood clotting. This may be a problem if you are having surgery or getting chemotherapy.

For moderate to severe pain

Opioids (also known as narcotics): Morphine, fentanyl, hydromorphone, oxycodone, and codeine may be used.

You need a written prescription for these medicines. Non-opioids may be used along with opioids for moderate to severe pain to get the best effect.

For breakthrough pain

Rapid-onset opioids: Fast acting oral morphine; fentanyl in a lozenge or "sucker" form (these forms of fentanyl absorb directly from your mouth as you suck on them, they are not swallowed)

You need a written prescription for these medicines. A short-acting opioid, which relieves breakthrough pain quickly, is often used with a long-acting opioid for chronic pain.

For tingling and burning pain

Antidepressants: Amitriptyline, nortriptyline, and desipramine.

You need a prescription for these medicines. Antidepressants are also prescribed to relieve some types of pain. Taking an antidepressant does not mean that you are depressed or have a mental illness.

Anti-convulsants (anti-seizure medicines): Carbamazepine, gabapentin, and phenytoin

You need a prescription for these medicines. Despite the name, anti-convulsants are used not only for convulsions, but also to control burning and tingling pain.

For pain caused by swelling or pressure

Steroids: Prednisone, dexamethasone.

You need a prescription for these medicines. They are used to lessen swelling, which often causes pressure and pain.

How is pain medicine given?

Some people think that if their pain becomes severe, they will need to get injections or "shots" of pain medicine. In fact, shots are rarely given to relieve cancer pain. There are many other ways you can take pain medicine.

* Oral -- means the drug is taken by mouth, either by being swallowed or melted in the mouth. Medicine is given as a liquid, pill, capsule, or in transmucosal form (lozenge or "sucker" where the drug absorbs directly from the mouth).

* Skin patch -- a clear, bandage-like patch placed on the skin, which slowly but continuously releases the medicine through the skin for 2 to 3 days. This form of medicine is less likely to cause nausea and vomiting.

* Rectal suppositories -- medicine that dissolves in the rectum and is absorbed by the body.

* Injections

Subcutaneous (SC) injection -- medicine is placed just under the skin using a small needle.

Intravenous (IV) injection -- medicine goes directly into the vein through a needle, port, or catheter.

Intrathecal and epidural injections -- medicine is placed directly into the fluid around the spinal cord (intrathecal) or into the space around the spinal cord (epidural).

* Pump, or patient-controlled analgesia (PCA) -- with this method, you can help control the amount of pain medicine you take. When you need pain relief, you can press a button to get a pre-set dose of pain medicine through a computerized pump that is connected to a small tube going into your body. The medicine is injected into a vein (intravenously), just under the skin (subcutaneously), or into the area around the spine.

What are the side effects of pain medicine?

All drugs have side effects and pain killers are no exception.Each type of pain medicine however has its own peculiar side effects, even those that you can buy over the counter.

-Some, such as aspirin or ibuprofen (and others in that family of drugs) can cause stomach irritation, or even bleeding from ulcerations, and should be taken with food.

-Many side effects from opioid pain medicine can be prevented. Constipation, for instance, is easier to prevent than to treat. Most doctors will start you on a plan to prevent constipation at the same time they start your opioid pain medicines. Some mild side effects such as nausea, itching, or drowsiness, often go away without further treatment after a few days, as your body adjusts to the medicine. Let your doctor or nurse know if you are having any side effects and ask for help in managing them.

-More serious side effects of pain medicine are rare. As with the more common ones, they often happen in the first few hours of treatment. These serious side effects are: difficulty in breathing,dizziness, and rashes. If you have any of these side effects, you should call your doctor right away.

You should avoid taking medicines to calm you down (sedatives or tranquilizers), alcohol, or take sleeping pills, when you are on opoids as you raise your risk of serious side effects from opioids.Taking opoids and these other drugs has led to the deaths of some people. Make sure you discuss with your doctor before you start taking opioids for pain.

Also the use of aspirin, ibuprofen, and other NSAIDs are contraindicated{should be avoided totally} when you are having chemotherapy. If you are on mesothelioma chemotherapy make sure you discuss with your doctor before you take non-prescription pain relievers.